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Bret A Hassel Selected Research

2-5A-dependent ribonuclease (RNase L)

10/2014RNase L interacts with Filamin A to regulate actin dynamics and barrier function for viral entry.
7/2014Enteropathogenic Escherichia coli inhibits type I interferon- and RNase L-mediated host defense to disrupt intestinal epithelial cell barrier function.
4/2014RNase-L control of cellular mRNAs: roles in biologic functions and mechanisms of substrate targeting.
5/2013RNase-L deficiency exacerbates experimental colitis and colitis-associated cancer.
1/2013Regulation of human RNase-L by the miR-29 family reveals a novel oncogenic role in chronic myelogenous leukemia.
1/2012Pathologic effects of RNase-L dysregulation in immunity and proliferative control.
7/2009Ribosomal protein mRNAs are primary targets of regulation in RNase-L-induced senescence.
3/2007Post-transcriptional regulation of RNase-L expression is mediated by the 3'-untranslated region of its mRNA.

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Bret A Hassel Research Topics

Disease

10Neoplasms (Cancer)
05/2013 - 04/2004
3Infections
10/2014 - 04/2014
2Carcinogenesis
04/2014 - 12/2008
2Breast Neoplasms (Breast Cancer)
07/2006 - 05/2006
1Prostatic Neoplasms (Prostate Cancer)
07/2015
1Virus Diseases (Viral Diseases)
10/2014
1Colitis-Associated Neoplasms
05/2013
1Colitis
05/2013
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
01/2013
1Hematologic Neoplasms (Hematological Malignancy)
01/2013
1Lung Neoplasms (Lung Cancer)
12/2008
1Choriocarcinoma
05/2006
1Acute Promyelocytic Leukemia
04/2004
1Leukemia
04/2004

Drug/Important Bio-Agent (IBA)

82-5A-dependent ribonuclease (RNase L)IBA
10/2014 - 03/2007
5Proteins (Proteins, Gene)FDA Link
07/2015 - 05/2006
3Antiviral Agents (Antivirals)IBA
10/2014 - 03/2007
2EndoribonucleasesIBA
10/2014 - 01/2013
2InterferonsIBA
04/2014 - 01/2013
2Messenger RNA (mRNA)IBA
05/2006 - 04/2004
1Lapatinib (GW572016)FDA Link
07/2015
1ErbB Receptors (EGF Receptor)IBA
07/2015
12',5'-oligoadenylate (PAPAPA)IBA
10/2014
1FilaminsIBA
10/2014
1Biological ProductsIBA
04/2014
1Bacterial RNAIBA
05/2013
1Ribonucleases (Ribonuclease)IBA
05/2013
1Dextran SulfateIBA
05/2013
1AzoxymethaneIBA
05/2013
1MicroRNAs (MicroRNA)IBA
01/2013
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2012
1RNA (Ribonucleic Acid)IBA
01/2011
1Cyclin D1IBA
12/2008
1Bexarotene (LGD1069)FDA Link
12/2008
1Imatinib Mesylate (Gleevec)FDA Link
07/2006
1Tyrosine Kinase InhibitorsIBA
07/2006
1Pharmaceutical PreparationsIBA
05/2006
15' Untranslated Regions (5' UTR)IBA
05/2006
1Retinoic Acid Receptor alphaIBA
04/2004
1Tretinoin (Retinoic Acid)FDA LinkGeneric
04/2004
1RetinoidsIBA
04/2004